8CUL

Xray ray crystal structure of OXA-24/40 in complex with CR167

Summary for 8CUL

Entry DOI	10.2210/pdb8cul/pdb
Descriptor	Beta-lactamase, 3-({[(dihydroxyboranyl)methyl]sulfamoyl}methyl)benzoic acid (3 entities in total)
Functional Keywords	carbapenemase, batsi, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Acinetobacter baumannii
Total number of polymer chains	1
Total formula weight	27990.92
Authors	Fernando, M.C.,Wallar, B.J.,Powers, R.A. (deposition date: 2022-05-17, release date: 2023-04-05, Last modification date: 2023-11-15)
Primary citation	Introvigne, L.M.,Beardsley, T.J.,Fernando, M.C.,Leonard, D.A.,Wallar, B.J.,Rudin, S.D.,Taracila, M.A.,Rather, P.N.,Colquhoun, J.M.,Song, S.,Fini, F.,Hujer, K.M.,Hujer, A.M.,Prati, F.,Powers, R.A.,Bonomo, R.A.,Caselli, E. Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii Antibiotics, 12:644-, 2023 Cited by DOI: 10.3390/antibiotics12040644 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation