8CN9

Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII

Summary for 8CN9

• Entry DOI: 10.2210/pdb8cn9/pdb
• Descriptor: Fab light chain, Fab heavy chain, Coagulation factor VII, ... (8 entities in total)
• Functional Keywords: factor vii, fab, bispecific antibody, hmb-001, blood clotting
• Biological source: Homo sapiens; More
• Total number of polymer chains: 20
• Total formula weight: 446753.59

Authors

Schluckebier, G.,Johansson, E. (deposition date: 2023-02-22, release date: 2023-12-27)

• Primary citation: Gandhi, P.S.,Zivkovic, M.,Oestergaard, H.,Bonde, A.C.,Loevgreen, M.N.,Schluckebier, G.,Johansson, E.,Rea, C.J.,Soerensen, B.,Schutgens, R.E.,Urbanus, R.T.,Faber, J.H.; A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders; Nat Cardiovasc Res, 2023

Experimental method

X-RAY DIFFRACTION (3.4 Å)