8CLH

Drug cocktail (Colchicine, Epothilone A, Peloruside, Ansamitocin P3, Vinblastine) bound to tubulin (T2R-TTL) complex

Summary for 8CLH

• Entry DOI: 10.2210/pdb8clh/pdb
• Descriptor: Tubulin alpha-1B chain, EPOTHILONE A, Peloruside A, ... (15 entities in total)
• Functional Keywords: drug-tubulin-complex cell cycle inhibition, cell cycle
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 260696.54

Authors

Wranik, M.,Bertrand, Q.,Kepa, M.W.,Weinert, T.,Steinmetz, M.,Standfuss, J. (deposition date: 2023-02-16, release date: 2023-12-13)

• Primary citation: Wranik, M.,Kepa, M.W.,Beale, E.V.,James, D.,Bertrand, Q.,Weinert, T.,Furrer, A.,Glover, H.,Gashi, D.,Carrillo, M.,Kondo, Y.,Stipp, R.T.,Khusainov, G.,Nass, K.,Ozerov, D.,Cirelli, C.,Johnson, P.J.M.,Dworkowski, F.,Beale, J.H.,Stubbs, S.,Zamofing, T.,Schneider, M.,Krauskopf, K.,Gao, L.,Thorn-Seshold, O.,Bostedt, C.,Bacellar, C.,Steinmetz, M.O.,Milne, C.,Standfuss, J.; A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers.; Nat Commun, 14:7956-7956, 2023; PubMed: 38042952; DOI: 10.1038/s41467-023-43523-5

Experimental method

X-RAY DIFFRACTION (2.5 Å)