8CHV
Crystal structure of human PURA (fragment Glu57-Glu212, PUR repeat I and II) R140P mutant
Summary for 8CHV
Entry DOI | 10.2210/pdb8chv/pdb |
Descriptor | Transcriptional activator protein Pur-alpha (2 entities in total) |
Functional Keywords | rna/dna binding, pur repeat, pc4-like fold, rna binding protein, pura syndrome |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 70732.05 |
Authors | Janowski, R.,Niessing, D. (deposition date: 2023-02-08, release date: 2024-02-21, Last modification date: 2024-05-08) |
Primary citation | Proske, M.,Janowski, R.,Bacher, S.,Kang, H.S.,Monecke, T.,Koehler, T.,Hutten, S.,Tretter, J.,Crois, A.,Molitor, L.,Varela-Rial, A.,Fino, R.,Donati, E.,De Fabritiis, G.,Dormann, D.,Sattler, M.,Niessing, D. PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association. Elife, 13:-, 2024 Cited by PubMed: 38655849DOI: 10.7554/eLife.93561 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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