8CHS

Human heparan sulfate N-deacetylase-N-sulfotransferase 1 in complex with calcium, 3'-phosphoadenosine-5'-phosphosulfate and nanobody nAb13 (composite map and model).

Summary for 8CHS

Entry DOI	10.2210/pdb8chs/pdb
Related	8CCY 8CD0 8CHS
EMDB information	16664
Descriptor	Nanobody nAb13 - all CA rigid fit model derived from nanobody nAb7, Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1, ADENOSINE-3'-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	deacetylase, sulfotransferase, heparan sulfate, carbohydrate, glycosaminoglycan, nanobody
Biological source	Lama glama More
Total number of polymer chains	2
Total formula weight	110588.10
Authors	Mycroft-West, C.J.,Wu, L. (deposition date: 2023-02-08, release date: 2024-02-21, Last modification date: 2024-02-28)
Primary citation	Mycroft-West, C.J.,Abdelkarim, S.,Duyvesteyn, H.M.E.,Gandhi, N.S.,Skidmore, M.A.,Owens, R.J.,Wu, L. Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1. Nat Commun, 15:1326-1326, 2024 Cited by PubMed: 38351061 DOI: 10.1038/s41467-024-45419-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.15 Å)

Structure validation