8CDG

Crystal structure of human IL-17A cytokine in complex with macrocycle

Summary for 8CDG

Entry DOI	10.2210/pdb8cdg/pdb
Descriptor	Interleukin-17A, (9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid (2 entities in total)
Functional Keywords	inhibitor, complex, cytokine, macrocycle
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	29405.15
Authors	Schulze, M.-S. (deposition date: 2023-01-30, release date: 2023-12-06)
Primary citation	Shaw, D.J.,Waters, L.C.,Strong, S.L.,Schulze, M.E.D.,Greetham, G.M.,Towrie, M.,Parker, A.W.,Prosser, C.E.,Henry, A.J.,Lawson, A.D.G.,Carr, M.D.,Taylor, R.J.,Hunt, N.T.,Muskett, F.W. Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism. Chem Sci, 14:7524-7536, 2023 Cited by PubMed: 37449080 DOI: 10.1039/d3sc00728f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation