8CBU

HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor MUT884

Summary for 8CBU

Entry DOI	10.2210/pdb8cbu/pdb
Descriptor	Integrase, CHLORIDE ION, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywords	integrase, hiv, allini, allosteric inhibitor, inhibitor, retrovirus, inlai, ncini, mini, ledgin, mutabilis, mut884, viral protein
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	4
Total formula weight	105071.83
Authors	Singer, M.R.,Pye, V.E.,Yu, Z.,Cherepanov, P. (deposition date: 2023-01-25, release date: 2023-06-07, Last modification date: 2023-07-26)
Primary citation	Bonnard, D.,Le Rouzic, E.,Singer, M.R.,Yu, Z.,Le Strat, F.,Batisse, C.,Batisse, J.,Amadori, C.,Chasset, S.,Pye, V.E.,Emiliani, S.,Ledoussal, B.,Ruff, M.,Moreau, F.,Cherepanov, P.,Benarous, R. Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase. Antimicrob.Agents Chemother., 67:e0046223-e0046223, 2023 Cited by PubMed: 37310224 DOI: 10.1128/aac.00462-23 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.44 Å)

Structure validation