8BZI

Human MST3 (STK24) kinase in complex with inhibitor MR39

Summary for 8BZI

Entry DOI	10.2210/pdb8bzi/pdb
Descriptor	Serine/threonine-protein kinase 24, 8-(4-azanylbutyl)-6-[2,5-bis(fluoranyl)-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	selective kinase inhibitors, structure-based drug design, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35196.34
Authors	Balourdas, D.I.,Rak, M.,Tesch, R.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2022-12-14, release date: 2023-01-18, Last modification date: 2024-02-07)
Primary citation	Rak, M.,Tesch, R.,Berger, L.M.,Shevchenko, E.,Raab, M.,Tjaden, A.,Zhubi, R.,Balourdas, D.I.,Joerger, A.C.,Poso, A.,Kramer, A.,Elson, L.,Lucic, A.,Kronenberger, T.,Hanke, T.,Strebhardt, K.,Sanhaji, M.,Knapp, S. Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily. Eur.J.Med.Chem., 254:115347-115347, 2023 Cited by PubMed: 37094449 DOI: 10.1016/j.ejmech.2023.115347 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation