8BUH

Structure of DDB1 bound to WX3-engaged CDK12-cyclin K

Summary for 8BUH

Entry DOI	10.2210/pdb8buh/pdb
Descriptor	DNA damage-binding protein 1, Cyclin-dependent kinase 12, Cyclin-K, ... (5 entities in total)
Functional Keywords	kinase, cyclin, ubiquitin, degrader, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	9
Total formula weight	499056.03
Authors	Kozicka, Z.,Kempf, G.,Focht, V.,Thoma, N.H. (deposition date: 2022-11-30, release date: 2023-09-13, Last modification date: 2024-03-27)
Primary citation	Kozicka, Z.,Suchyta, D.J.,Focht, V.,Kempf, G.,Petzold, G.,Jentzsch, M.,Zou, C.,Di Genua, C.,Donovan, K.A.,Coomar, S.,Cigler, M.,Mayor-Ruiz, C.,Schmid-Burgk, J.L.,Haussinger, D.,Winter, G.E.,Fischer, E.S.,Slabicki, M.,Gillingham, D.,Ebert, B.L.,Thoma, N.H. Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20:93-102, 2024 Cited by PubMed: 37679459 DOI: 10.1038/s41589-023-01409-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.79 Å)

Structure validation