8BST

Crystal structure of the kainate receptor GluK3-H523A ligand binding domain in complex with kainate at 2.7A resolution

Summary for 8BST

• Entry DOI: 10.2210/pdb8bst/pdb
• Descriptor: Glutamate receptor ionotropic, kainate 3, ACETATE ION, ZINC ION, ... (9 entities in total)
• Functional Keywords: ionotropic glutamate receptor, gluk3 ligand-binding domain, membrane protein, gluk3-m523a-lbd
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 4
• Total formula weight: 119934.42

Authors

Venskutonyte, R.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2022-11-26, release date: 2023-12-13, Last modification date: 2024-04-10)

• Primary citation: Bay, Y.,Venskutonyte, R.,Frantsen, S.M.,Thorsen, T.S.,Musgaard, M.,Frydenvang, K.,Francotte, P.,Pirotte, B.,Biggin, P.C.,Kristensen, A.S.,Boesen, T.,Pickering, D.S.,Gajhede, M.,Kastrup, J.S.; Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.; Febs J., 291:1506-1529, 2024; PubMed: 38145505; DOI: 10.1111/febs.17046

Experimental method

X-RAY DIFFRACTION (2.7 Å)