8BQU

Molecular basis of ZP3/ZP1 heteropolymerization: crystal structure of a native vertebrate egg coat filament

Summary for 8BQU

• Entry DOI: 10.2210/pdb8bqu/pdb
• Related: 3NK4 5BUP 5OSQ 6TQK 8RKI
• Descriptor: Zona pellucida sperm-binding protein 3, Choriogenin H, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: cell adhesion, fertilization, egg-sperm interaction, gamete recognition, sperm receptor, extracellular matrix, egg coat, zona pellucida, vitelline envelope, fish chorion, glycoprotein, n-glycan, structural protein, zp module, zp-n domain, zp_c domain, trefoil domain, medaka, japanese rice fish
• Biological source: Oryzias latipes (Japanese medaka); More
• Total number of polymer chains: 3
• Total formula weight: 72759.76

Authors

Bokhove, M.,de Sanctis, D.,Yasumasu, S.,Jovine, L. (deposition date: 2022-11-21, release date: 2024-03-13, Last modification date: 2024-03-27)

• Primary citation: Nishio, S.,Emori, C.,Wiseman, B.,Fahrenkamp, D.,Dioguardi, E.,Zamora-Caballero, S.,Bokhove, M.,Han, L.,Stsiapanava, A.,Algarra, B.,Lu, Y.,Kodani, M.,Bainbridge, R.E.,Komondor, K.M.,Carlson, A.E.,Landreh, M.,de Sanctis, D.,Yasumasu, S.,Ikawa, M.,Jovine, L.; ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat.; Cell, 187:1440-1459.e24, 2024; PubMed: 38490181; DOI: 10.1016/j.cell.2024.02.013

Experimental method

X-RAY DIFFRACTION (2.7 Å)