8BLA

Human serotonin 5-HT3A receptor in complex with vortioxetine (detergent, ECD only, active/distorted conformation)

Summary for 8BLA

• Entry DOI: 10.2210/pdb8bla/pdb
• Related: 8AW2 8AXD
• EMDB information: 16104
• Descriptor: 5-hydroxytryptamine receptor 3A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: human pentameric ligand-gated ion channel, human serotonin receptor, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 238772.44

Authors

Lopez-Sanchez, U.,Nury, H. (deposition date: 2022-11-09, release date: 2024-05-15)

• Primary citation: Lopez-Sanchez, U.,Munro, L.J.,Ladefoged, L.K.,Pedersen, A.J.,Brun, C.C.,Lyngby, S.M.,Baud, D.,Juillan-Binard, C.,Pedersen, M.G.,Lummis, S.C.R.,Bang-Andersen, B.,Schiott, B.,Chipot, C.,Schoehn, G.,Neyton, J.,Dehez, F.,Nury, H.,Kristensen, A.S.; Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors.; Nat.Struct.Mol.Biol., 2024; PubMed: 38698207; DOI: 10.1038/s41594-024-01282-x

Experimental method

ELECTRON MICROSCOPY (3.3 Å)