8BJH

chimera of the inactive ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, with the double mutation K3528M and K3535I, fused to a proline-Rich-Domain (PRD) and profilin, bound to Latrunculin B-ADP-Mg-actin

Summary for 8BJH

• Entry DOI: 10.2210/pdb8bjh/pdb
• Related: 7PJ0 7PQJ 7PSB
• Descriptor: Actin, alpha skeletal muscle, intermediate form, DI(HYDROXYETHYL)ETHER, Putative Adenylate cyclase,Profilin-1, ... (11 entities in total)
• Functional Keywords: bacterial nucleotidyl cyclase toxin, activated complex, toxin
• Biological source: Vibrio nigripulchritudo; More
• Total number of polymer chains: 2
• Total formula weight: 109019.43

Authors

Teixeira-Nunes, M.,Renault, L.,Retailleau, P. (deposition date: 2022-11-04, release date: 2023-09-20, Last modification date: 2023-10-04)

• Primary citation: Teixeira-Nunes, M.,Retailleau, P.,Raoux-Barbot, D.,Comisso, M.,Missinou, A.A.,Velours, C.,Plancqueel, S.,Ladant, D.,Mechold, U.,Renault, L.; Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin.; Plos Pathog., 19:e1011654-e1011654, 2023; PubMed: 37747912; DOI: 10.1371/journal.ppat.1011654

Experimental method

X-RAY DIFFRACTION (1.69 Å)