8BIK

Crystal structure of human AMPK heterotrimer in complex with allosteric activator C455

Summary for 8BIK

• Entry DOI: 10.2210/pdb8bik/pdb
• Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (7 entities in total)
• Functional Keywords: ampk activator, allosteric activator, adam site, structure-based drug design, selectivity, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 266753.78

Authors

Schimpl, M.,Mather, K.M.,Boland, M.L.,Rivers, E.L.,Srivastava, A.,Hemsley, P.,Robinson, J.,Wan, P.T.,Hansen, J.,Read, J.A.,Trevaskis, J.L.,Smith, D.M. (deposition date: 2022-11-02, release date: 2024-05-15)

• Primary citation: Mather, K.M.; A Direct AMPK Activator Reduces Liver Steatosis but Does Not Alter Fibrosis in a Mouse Model of Non-Alcoholic Steatohepatitis; To be published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)