8BGC

Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with compound 2 (AA-CS-9-003)

Summary for 8BGC

Entry DOI	10.2210/pdb8bgc/pdb
Descriptor	Casein kinase II subunit alpha, SULFATE ION, 5-[(phenylmethyl)amino]pyrimido[4,5-c]quinoline-8-carboxylic acid, ... (4 entities in total)
Functional Keywords	ck2apha, kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	82277.26
Authors	Kraemer, A.,Axtman, A.D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2022-10-27, release date: 2022-11-23, Last modification date: 2024-01-31)
Primary citation	Davis-Gilbert, Z.W.,Kramer, A.,Dunford, J.E.,Howell, S.,Senbabaoglu, F.,Wells, C.I.,Bashore, F.M.,Havener, T.M.,Smith, J.L.,Hossain, M.A.,Oppermann, U.,Drewry, D.H.,Axtman, A.D. Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2. Acs Med.Chem.Lett., 14:432-441, 2023 Cited by PubMed: 37077385 DOI: 10.1021/acsmedchemlett.2c00530 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation