8BAC

Crystal structure of human heparanase in complex with competitive inhibitor GD05

This is a non-PDB format compatible entry.

Summary for 8BAC

• Entry DOI: 10.2210/pdb8bac/pdb
• Descriptor: Heparanase 50 kDa subunit, Heparanase 8 kDa subunit, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: inhibitor complex, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 52672.48

Authors

Armstrong, Z.,Davies, G.J. (deposition date: 2022-10-11, release date: 2023-03-01, Last modification date: 2024-02-07)

• Primary citation: Doherty, G.G.,Ler, G.J.M.,Wimmer, N.,Bernhardt, P.V.,Ashmus, R.A.,Vocadlo, D.J.,Armstrong, Z.,Davies, G.J.,Maccarana, M.,Li, J.P.,Kayal, Y.,Ferro, V.; Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of alpha-Iduronidase, beta-Glucuronidase and Heparanase.; Chembiochem, 24:e202200619-e202200619, 2023; PubMed: 36453606; DOI: 10.1002/cbic.202200619

Experimental method

X-RAY DIFFRACTION (2.05 Å)