8B0C

Crystal structure of human heparanase in complex with covalent inhibitor VB158

This is a non-PDB format compatible entry.

Summary for 8B0C

• Entry DOI: 10.2210/pdb8b0c/pdb
• Descriptor: Heparanase 50 kDa subunit, Heparanase 8 kDa subunit, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: heparanase, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 52603.28

Authors

Armstrong, Z.,Davies, G. (deposition date: 2022-09-07, release date: 2022-12-28, Last modification date: 2024-02-07)

• Primary citation: Borlandelli, V.,Armstrong, Z.,Nin-Hill, A.,Codee, J.D.C.,Raich, L.,Artola, M.,Rovira, C.,Davies, G.J.,Overkleeft, H.S.; 4-O-Substituted Glucuronic Cyclophellitols are Selective Mechanism-Based Heparanase Inhibitors.; Chemmedchem, 18:e202200580-e202200580, 2023; PubMed: 36533564; DOI: 10.1002/cmdc.202200580

Experimental method

X-RAY DIFFRACTION (2.1 Å)