8AXH

Crystal structure of a MUC1-like glycopeptide containing the unnatural L-4-hydroxynorvaline in complex with scFv-SM3

Summary for 8AXH

Entry DOI	10.2210/pdb8axh/pdb
Descriptor	Single-chain variable antibody (scFv) SM3, Mucin-1 subunit alpha, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	immune system
Biological source	Mus musculus More
Total number of polymer chains	2
Total formula weight	27020.70
Authors	Bermejo, I.,Corzana, F.,Hurtado-Guerrero, R. (deposition date: 2022-08-31, release date: 2023-08-09, Last modification date: 2024-02-21)
Primary citation	Bermejo, I.A.,Guerreiro, A.,Eguskiza, A.,Martinez-Saez, N.,Lazaris, F.S.,Asin, A.,Somovilla, V.J.,Companon, I.,Raju, T.K.,Tadic, S.,Garrido, P.,Garcia-Sanmartin, J.,Mangini, V.,Grosso, A.S.,Marcelo, F.,Avenoza, A.,Busto, J.H.,Garcia-Martin, F.,Hurtado-Guerrero, R.,Peregrina, J.M.,Bernardes, G.J.L.,Martinez, A.,Fiammengo, R.,Corzana, F. Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses. Jacs Au, 4:150-163, 2024 Cited by PubMed: 38274250 DOI: 10.1021/jacsau.3c00587 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation