8AWR

Structure of recombinant human beta-glucocerebrosidase in complex with L-carbaxylosyl chloride

This is a non-PDB format compatible entry.

Summary for 8AWR

• Entry DOI: 10.2210/pdb8awr/pdb
• Related: 8AWK
• Descriptor: Lysosomal acid glucosylceramidase, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (10 entities in total)
• Functional Keywords: beta-glucocerebrosidase, glycoside hydrolase, inhibitor, carbasugar, pharmacological chaperone, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 58934.85

Authors

Rowland, R.J.,Davies, G.J. (deposition date: 2022-08-30, release date: 2024-03-13)

• Primary citation: Bhosale, S.,Kandalkar, S.,Gilormini, P.A.,Akintola, O.,Rowland, R.J.,Adabala, P.J.P.,King, D.,Deen, M.C.,Xi, K.,Davies, G.J.,Vocadlo, D.J.,Bennet, A.J.; Single turnover covalent inhibitors for functional chaperoning of lysosomal glycoside hydrolases; To be published,

Experimental method

X-RAY DIFFRACTION (1.49 Å)