8AQT

Beta SARS-CoV-2 Spike bound to mouse ACE2 (local)

Summary for 8AQT

Entry DOI	10.2210/pdb8aqt/pdb
EMDB information	15541 15589
Descriptor	Processed angiotensin-converting enzyme 2,Ig gamma-2A chain C region, membrane-bound form, Spike glycoprotein,Fibritin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	sars-cov2, omicron, spike, rbd, mouse, ace2, antiviral protein, beta, viral protein
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	2
Total formula weight	244773.98
Authors	Lau, K.,Ni, D.,Beckert, B.,Nazarov, S.,Myasnikov, A.,Pojer, F.,Stahlberg, H.,Uchikawa, E. (deposition date: 2022-08-13, release date: 2023-03-01, Last modification date: 2023-04-19)
Primary citation	Ni, D.,Turelli, P.,Beckert, B.,Nazarov, S.,Uchikawa, E.,Myasnikov, A.,Pojer, F.,Trono, D.,Stahlberg, H.,Lau, K. Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range. Plos Pathog., 19:e1011206-e1011206, 2023 Cited by PubMed: 37018380 DOI: 10.1371/journal.ppat.1011206 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.4 Å)

Structure validation