8AE4

Crystal structure of human legumain in complex with Clitocypin 2

Summary for 8AE4

Entry DOI	10.2210/pdb8ae4/pdb
Descriptor	Legumain, Clitocypin-2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	cysteine protease, ligase, asparaginyl endopeptidase, aep, inhibitor, exosite, active site, substrate, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	49053.69
Authors	Elamin, T.,Brandstetter, H.,Dall, E. (deposition date: 2022-07-12, release date: 2022-09-28, Last modification date: 2024-01-31)
Primary citation	Elamin, T.,Santos, N.P.,Briza, P.,Brandstetter, H.,Dall, E. Structural and functional studies of legumain-mycocypin complexes revealed a competitive, exosite-regulated mode of interaction. J.Biol.Chem., 298:102502-102502, 2022 Cited by PubMed: 36116553 DOI: 10.1016/j.jbc.2022.102502 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation