8A9Z

Tubulin-[1,2]oxazoloisoindole-2e complex

Summary for 8A9Z

Entry DOI	10.2210/pdb8a9z/pdb
Descriptor	Tubulin alpha-1B chain, 7-[(3,5-dimethoxyphenyl)methyl]pyrrolo[3,4-g][1,2]benzoxazole, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywords	cell cycle, tubulin fold, cytoskeleton, microtubule
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	6
Total formula weight	265178.80
Authors	Prota, A.E.,Abel, A.-C.,Steinmetz, M.O.,Barraja, P.,Montalbano, A.,Spano, V. (deposition date: 2022-06-29, release date: 2022-11-09, Last modification date: 2024-01-31)
Primary citation	Barreca, M.,Spano, V.,Rocca, R.,Bivacqua, R.,Abel, A.C.,Maruca, A.,Montalbano, A.,Raimondi, M.V.,Tarantelli, C.,Gaudio, E.,Cascione, L.,Rinaldi, A.,Bai, R.,Steinmetz, M.O.,Prota, A.E.,Alcaro, S.,Hamel, E.,Bertoni, F.,Barraja, P. Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. Eur.J.Med.Chem., 243:114744-114744, 2022 Cited by PubMed: 36242921 DOI: 10.1016/j.ejmech.2022.114744 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.294 Å)

Structure validation