8A7E

PAPP-A dimer in complex with its inhibitor STC2

Summary for 8A7E

• Entry DOI: 10.2210/pdb8a7e/pdb
• Related: 8A7D
• EMDB information: 15217 15219 15220 15221
• Descriptor: Stanniocalcin-2, Pappalysin-1, ZINC ION, ... (4 entities in total)
• Functional Keywords: metzincin metalloprotease inhibitor complex, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 380904.07

Authors

Kobbero, S.D.,Gajhede, M.,Mirza, O.A.,Boesen, T.,Oxvig, C. (deposition date: 2022-06-20, release date: 2022-11-02)

• Primary citation: Kobbero, S.D.,Gajhede, M.,Mirza, O.A.,Kloverpris, S.,Kjaer, T.R.,Mikkelsen, J.H.,Boesen, T.,Oxvig, C.; Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.; Nat Commun, 13:6084-6084, 2022; PubMed: 36257932; DOI: 10.1038/s41467-022-33698-8

Experimental method

ELECTRON MICROSCOPY (5.02 Å)