8A1O

Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with acrylamide analogue 8

Summary for 8A1O

Entry DOI	10.2210/pdb8a1o/pdb
Descriptor	L,D-transpeptidase 2, DIMETHYL SULFOXIDE, GLYCEROL, ... (8 entities in total)
Functional Keywords	l, d-transpeptidase, ldtmt2, inhibitor, covalent, antimicrobial protein
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	38736.60
Authors	de Munnik, M.,Lang, P.A.,Brem, J.,Schofield, C.J. (deposition date: 2022-06-01, release date: 2023-06-14, Last modification date: 2024-02-07)
Primary citation	de Munnik, M.,Lang, P.A.,De Dios Anton, F.,Cacho, M.,Bates, R.H.,Brem, J.,Rodriguez Miquel, B.,Schofield, C.J. High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors. Chem Sci, 14:7262-7278, 2023 Cited by PubMed: 37416715 DOI: 10.1039/d2sc06858c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation