7ZYN

Crystal Structure of EGFR-T790M/C797S in Complex with WZ4002

Summary for 7ZYN

Entry DOI	10.2210/pdb7zyn/pdb
Descriptor	Epidermal growth factor receptor, N-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	egfr, t790m/c797s, inhibitor, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	38405.82
Authors	Niggenaber, J.,Kleinboelting, S.,Mueller, M.P.,Rauh, D. (deposition date: 2022-05-25, release date: 2023-05-03, Last modification date: 2024-02-07)
Primary citation	Grabe, T.,Jeyakumar, K.,Niggenaber, J.,Schulz, T.,Koska, S.,Kleinbolting, S.,Beck, M.E.,Muller, M.P.,Rauh, D. Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines. Acs Med.Chem.Lett., 14:591-598, 2023 Cited by PubMed: 37197473 DOI: 10.1021/acsmedchemlett.2c00514 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation