7ZXW

Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with the 5-[(morpholin-4-yl)methyl]quinolin-8-ol inhibitor

Summary for 7ZXW

Entry DOI	10.2210/pdb7zxw/pdb
Related	6FSN 7ZHB 7ZKC 7ZLE 7ZLL 7ZLU
Descriptor	UDP-glucose-glycoprotein glucosyltransferase-like protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (7 entities in total)
Functional Keywords	glycoprotein, misfolding, transferase, endoplasmic reticulum, gt24, 5-[(morpholin-4-yl)methyl]quinolin-8-ol
Biological source	Thermochaetoides thermophila DSM 1495
Total number of polymer chains	1
Total formula weight	36884.78
Authors	Le Cornu, J.D.,Ibba, R.,Roversi, P.,Zitzmann, N. (deposition date: 2022-05-23, release date: 2022-11-30, Last modification date: 2024-01-31)
Primary citation	Caputo, A.T.,Ibba, R.,Le Cornu, J.D.,Darlot, B.,Hensen, M.,Lipp, C.B.,Marciano, G.,Vasiljevic, S.,Zitzmann, N.,Roversi, P. Crystal polymorphism in fragment-based lead discovery of ligands of the catalytic domain of UGGT, the glycoprotein folding quality control checkpoint. Front Mol Biosci, 9:960248-960248, 2022 Cited by PubMed: 36589243 DOI: 10.3389/fmolb.2022.960248 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.246 Å)

Structure validation