7ZWM

Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3

Summary for 7ZWM

• Entry DOI: 10.2210/pdb7zwm/pdb
• Descriptor: Gametocyte surface protein P45/48, 32F3 heavy chain, 32F3 light chain, ... (8 entities in total)
• Functional Keywords: pfs48/45, malaria, transmission-blocking, plasmodium falciparum, gamete, antibody, cell adhesion
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum); More
• Total number of polymer chains: 10
• Total formula weight: 400980.05

Authors

Ko, K.T.,Lennartz, F.L.,Higgins, M.K. (deposition date: 2022-05-19, release date: 2022-06-22, Last modification date: 2024-01-31)

• Primary citation: Ko, K.T.,Lennartz, F.,Mekhaiel, D.,Guloglu, B.,Marini, A.,Deuker, D.J.,Long, C.A.,Jore, M.M.,Miura, K.,Biswas, S.,Higgins, M.K.; Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.; Nat Commun, 13:5603-5603, 2022; PubMed: 36153317; DOI: 10.1038/s41467-022-33379-6

Experimental method

X-RAY DIFFRACTION (3.69 Å)