7ZUS

Crystal structure of ternary complex of Pol theta polymerase domain

This is a non-PDB format compatible entry.

Summary for 7ZUS

• Entry DOI: 10.2210/pdb7zus/pdb
• Descriptor: DNA polymerase theta, DNA (5'-D(P*TP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), ... (6 entities in total)
• Functional Keywords: dna polymerase, protein-dna complex, dna repair, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 9
• Total formula weight: 273338.87

Authors

Krajewski, W.W.,Turnbull, A.P.,Willis, S.,Charles, M.,Stockley, M.,Heald, R.A. (deposition date: 2022-05-13, release date: 2022-10-12, Last modification date: 2024-01-31)

• Primary citation: Stockley, M.L.,Ferdinand, A.,Benedetti, G.,Blencowe, P.,Boyd, S.M.,Calder, M.,Charles, M.D.,Edwardes, L.V.,Ekwuru, T.,Finch, H.,Galbiati, A.,Geo, L.,Grande, D.,Grinkevich, V.,Holliday, N.D.,Krajewski, W.W.,MacDonald, E.,Majithiya, J.B.,McCarron, H.,McWhirter, C.L.,Patel, V.,Pedder, C.,Rajendra, E.,Ranzani, M.,Rigoreau, L.J.M.,Robinson, H.M.R.,Schaedler, T.,Sirina, J.,Smith, G.C.M.,Swarbrick, M.E.,Turnbull, A.P.,Willis, S.,Heald, R.A.; Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.; J.Med.Chem., 65:13879-13891, 2022; PubMed: 36200480; DOI: 10.1021/acs.jmedchem.2c01142

Experimental method

X-RAY DIFFRACTION (2.26 Å)