7ZRB

Crystal structure of Beta-catenin Armadillo repeats domain in complex with the inhibitor RS6452

Summary for 7ZRB

Entry DOI	10.2210/pdb7zrb/pdb
Descriptor	Catenin beta-1, 4-bromanyl-~{N}-(3-pyridin-2-ylphenyl)benzenesulfonamide (3 entities in total)
Functional Keywords	beta-catenin, colon cancer, wnt pathway, cell adhesion
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	118345.85
Authors	Capelli, D.,Pochetti, G.,Montanari, R. (deposition date: 2022-05-04, release date: 2023-05-17, Last modification date: 2024-02-07)
Primary citation	Nalli, M.,Di Magno, L.,Wen, Y.,Liu, X.,D'Ambrosio, M.,Puxeddu, M.,Parisi, A.,Sebastiani, J.,Sorato, A.,Coluccia, A.,Ripa, S.,Di Pastena, F.,Capelli, D.,Montanari, R.,Masci, D.,Urbani, A.,Naro, C.,Sette, C.,Orlando, V.,D'Angelo, S.,Biagioni, S.,Bigogno, C.,Dondio, G.,Pastore, A.,Stornaiuolo, M.,Canettieri, G.,Liu, T.,Silvestri, R.,La Regina, G. Novel N -(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the beta-Catenin Armadillo Repeats Domain as an Anticancer Agent. Acs Pharmacol Transl Sci, 6:1087-1103, 2023 Cited by PubMed: 37470018 DOI: 10.1021/acsptsci.3c00092 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.434 Å)

Structure validation