7ZPY

Influenza polymerase A C-terminal domain of PA subunit with optimized small peptide inhibitor

Summary for 7ZPY

• Entry DOI: 10.2210/pdb7zpy/pdb
• Descriptor: Polymerase acidic protein, Peptide inhibitor (ASP-TYR-ASN-PRO-TYR-LEU-LEU-TYR-LEU-LYS), METHOXY-ETHOXYL, ... (4 entities in total)
• Functional Keywords: antiviral peptides, influenza a polymerase, protein-protein interaction, viral protein
• Biological source: Influenza A virus (A/California/07/2009(H1N1)); More
• Total number of polymer chains: 2
• Total formula weight: 54317.22

Authors

Radilova, K.,Brynda, J. (deposition date: 2022-04-29, release date: 2022-10-26, Last modification date: 2024-01-31)

• Primary citation: Radilova, K.,Zima, V.,Kral, M.,Machara, A.,Majer, P.,Hodek, J.,Weber, J.,Brynda, J.,Strmen, T.,Konvalinka, J.,Kozisek, M.; Thermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction.; Antiviral Res., 208:105449-105449, 2022; PubMed: 36265804; DOI: 10.1016/j.antiviral.2022.105449

Experimental method

X-RAY DIFFRACTION (1.9 Å)