7ZPC

CDK2 in complex 9K-DOS

Summary for 7ZPC

Entry DOI	10.2210/pdb7zpc/pdb
Descriptor	Cyclin-dependent kinase 2, ~{N}-(1-methylpyrazol-4-yl)-5-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxamide (3 entities in total)
Functional Keywords	cdk2, dos, med chem, inhibitor, cell cycle
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35079.68
Authors	Watt, J.E.,Martin, M.P.,Noble, M.E.N. (deposition date: 2022-04-27, release date: 2023-02-01, Last modification date: 2024-02-07)
Primary citation	Uguen, M.,Davison, G.,Sprenger, L.J.,Hunter, J.H.,Martin, M.P.,Turberville, S.,Watt, J.E.,Golding, B.T.,Noble, M.E.M.,Stewart, H.L.,Waring, M.J. Build-Couple-Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity. J.Med.Chem., 65:11322-11339, 2022 Cited by PubMed: 35943172 DOI: 10.1021/acs.jmedchem.2c00897 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation