7ZN7

Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and rat STAT2 CCD

Summary for 7ZN7

Entry DOI	10.2210/pdb7zn7/pdb
EMDB information	14802
Descriptor	DNA damage-binding protein 1, B27a, Signal transducer and activator of transcription, ... (4 entities in total)
Functional Keywords	interferon, ubiquitin-proteasome system, cullin-ring ubiquitin ligases (crl), ddb1, dcafs, viral dcaf (vdcaf), cytomegalovirus, stat2, irf9, virus
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	267251.72
Authors	Lauer, S.,Spahn, C.M.T.,Schwefel, D. (deposition date: 2022-04-20, release date: 2022-11-09, Last modification date: 2023-03-15)
Primary citation	Le-Trilling, V.T.K.,Banchenko, S.,Paydar, D.,Leipe, P.M.,Binting, L.,Lauer, S.,Graziadei, A.,Klingen, R.,Gotthold, C.,Burger, J.,Bracht, T.,Sitek, B.,Jan Lebbink, R.,Malyshkina, A.,Mielke, T.,Rappsilber, J.,Spahn, C.M.,Voigt, S.,Trilling, M.,Schwefel, D. Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. Embo J., 42:e112351-e112351, 2023 Cited by PubMed: 36762436 DOI: 10.15252/embj.2022112351 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.78 Å)

Structure validation