7ZIF

Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-480

Summary for 7ZIF

Entry DOI	10.2210/pdb7zif/pdb
Descriptor	Tryptophan 5-hydroxylase 1, FE (III) ION, (2R)-2-azanyl-5-[[2-[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]sulfanyl-3H-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, ... (5 entities in total)
Functional Keywords	tryptophan hydroxylase, serotonin biosynthesis, metal binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	38121.11
Authors	Schuetz, A.,Ziebart, N.,Weise, M.,Mallow, K.,Pfeifer, J.,Nazare, M.,Specker, E.,Heinemann, U. (deposition date: 2022-04-08, release date: 2022-09-07, Last modification date: 2024-01-31)
Primary citation	Specker, E.,Matthes, S.,Wesolowski, R.,Schutz, A.,Grohmann, M.,Alenina, N.,Pleimes, D.,Mallow, K.,Neuenschwander, M.,Gogolin, A.,Weise, M.,Pfeifer, J.,Ziebart, N.,Heinemann, U.,von Kries, J.P.,Nazare, M.,Bader, M. Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65:11126-11149, 2022 Cited by PubMed: 35921615 DOI: 10.1021/acs.jmedchem.2c00598 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86859719255 Å)

Structure validation