7Z9L

Phen-DC3 intercalation causes hybrid-to-antiparallel transformation of human telomeric DNA G-quadruplex

Summary for 7Z9L

• Entry DOI: 10.2210/pdb7z9l/pdb
• NMR Information: BMRB: 34714
• Descriptor: DNA (5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'), N2,N9-bis(1-methylquinolin-3-yl)-1,10-phenanthroline-2,9-dicarboxamide (2 entities in total)
• Functional Keywords: g quadruplex, ligand intercalation, nmr spectroscopy, mass spectrometry, dna
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 7838.30

Authors

Ghosh, A.,Trajkovski, M.,Teulade-Fichou, M.P.,Gabelica, V.,Plavec, J. (deposition date: 2022-03-21, release date: 2022-08-31, Last modification date: 2022-10-05)

• Primary citation: Ghosh, A.,Trajkovski, M.,Teulade-Fichou, M.P.,Gabelica, V.,Plavec, J.; Phen-DC 3 Induces Refolding of Human Telomeric DNA into a Chair-Type Antiparallel G-Quadruplex through Ligand Intercalation.; Angew.Chem.Int.Ed.Engl., 61:e202207384-e202207384, 2022; PubMed: 35993443; DOI: 10.1002/anie.202207384

Experimental method

SOLUTION NMR