7Z6C

Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-ispropyl-5-methyl-4-phenoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboxamide.

Summary for 7Z6C

• Entry DOI: 10.2210/pdb7z6c/pdb
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
• Functional Keywords: dihydroorotate dehydrogenase, inhibitor, complex, acute myeloid leukaemia., oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 41080.62

Authors

Alberti, M.,Lolli, M.L.,Boschi, D.,Sainas, S.,Rizzi, M.,Ferraris, D.M.,Miggiano, R. (deposition date: 2022-03-11, release date: 2022-10-12, Last modification date: 2024-01-31)

• Primary citation: Sainas, S.,Giorgis, M.,Circosta, P.,Poli, G.,Alberti, M.,Passoni, A.,Gaidano, V.,Pippione, A.C.,Vitale, N.,Bonanni, D.,Rolando, B.,Cignetti, A.,Ramondetti, C.,Lanno, A.,Ferraris, D.M.,Canepa, B.,Buccinna, B.,Piccinini, M.,Rizzi, M.,Saglio, G.,Al-Karadaghi, S.,Boschi, D.,Miggiano, R.,Tuccinardi, T.,Lolli, M.L.; Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold: SAR of the Aryloxyaryl Moiety.; J.Med.Chem., 65:12701-12724, 2022; PubMed: 36162075; DOI: 10.1021/acs.jmedchem.2c00496

Experimental method

X-RAY DIFFRACTION (1.85 Å)