7Z3L

Autotaxin in complex with hybrid compound ziritaxestat (GLPG1690)

This is a non-PDB format compatible entry.

Summary for 7Z3L

• Entry DOI: 10.2210/pdb7z3l/pdb
• Descriptor: Isoform 2 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 2-[[2-ethyl-8-methyl-6-[4-[2-(3-oxidanylazetidin-1-yl)-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose, ... (11 entities in total)
• Functional Keywords: enpp2, lysophosphatidic acid, lipid chaperone, ; pulmonary fibrosis, gpcr, drug development, small-molecule inhibitor, hydrolase
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 1
• Total formula weight: 97312.47

Authors

Salgado-Polo, F.,Ford, P.,Heckmann, B.,Perrakis, A. (deposition date: 2022-03-02, release date: 2023-01-25, Last modification date: 2024-02-07)

• Primary citation: Salgado-Polo, F.,Borza, R.,Matsoukas, M.T.,Marsais, F.,Jagerschmidt, C.,Waeckel, L.,Moolenaar, W.H.,Ford, P.,Heckmann, B.,Perrakis, A.; Autotaxin facilitates selective LPA receptor signaling.; Cell Chem Biol, 30:69-84.e14, 2023; PubMed: 36640760; DOI: 10.1016/j.chembiol.2022.12.006

Experimental method

X-RAY DIFFRACTION (2.4 Å)