7Z3K

Autotaxin in complex with orthosteric site-binder CpdA

This is a non-PDB format compatible entry.

Summary for 7Z3K

• Entry DOI: 10.2210/pdb7z3k/pdb
• Descriptor: Isoform 2 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, GLYCEROL, [(2~{S},4~{R})-4-[2-[(3,5-dimethylphenyl)amino]-5,7-dihydropyrrolo[3,4-d]pyrimidin-6-yl]-2-methyl-piperidin-1-yl]-(6-fluoranyl-1~{H}-benzotriazol-5-yl)methanone, ... (12 entities in total)
• Functional Keywords: enpp2, lysophosphatidic acid, lipid chaperone, ; pulmonary fibrosis, gpcr, drug development, small-molecule inhibitor, hydrolase
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 1
• Total formula weight: 97649.49

Authors

Salgado-Polo, F.,Ford, P.,Heckmann, B.,Perrakis, A. (deposition date: 2022-03-02, release date: 2023-01-25, Last modification date: 2024-02-07)

• Primary citation: Salgado-Polo, F.,Borza, R.,Matsoukas, M.T.,Marsais, F.,Jagerschmidt, C.,Waeckel, L.,Moolenaar, W.H.,Ford, P.,Heckmann, B.,Perrakis, A.; Autotaxin facilitates selective LPA receptor signaling.; Cell Chem Biol, 30:69-84.e14, 2023; PubMed: 36640760; DOI: 10.1016/j.chembiol.2022.12.006

Experimental method

X-RAY DIFFRACTION (2 Å)