7Z21
BAF A12T bound to the lamin A/C Ig-fold domain
Summary for 7Z21
| Entry DOI | 10.2210/pdb7z21/pdb |
| Descriptor | Barrier-to-autointegration factor, N-terminally processed, Lamin-A/C, CHLORIDE ION, ... (4 entities in total) |
| Functional Keywords | complex, lamin a/c, baf, protein binding |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 6 |
| Total formula weight | 74430.93 |
| Authors | Marcelot, A.,Legrand, P.,Zinn-Justin, S. (deposition date: 2022-02-25, release date: 2022-08-24, Last modification date: 2024-01-31) |
| Primary citation | Janssen, A.,Marcelot, A.,Breusegem, S.,Legrand, P.,Zinn-Justin, S.,Larrieu, D. The BAF A12T mutation disrupts lamin A/C interaction, impairing robust repair of nuclear envelope ruptures in Nestor-Guillermo progeria syndrome cells. Nucleic Acids Res., 50:9260-9278, 2022 Cited by PubMed: 36039758DOI: 10.1093/nar/gkac726 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.629 Å) |
Structure validation
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