7Z1X
Crystal structure of human Gasdermin D complexed with nanobodies VHH-2 and VHH-6
Summary for 7Z1X
Entry DOI | 10.2210/pdb7z1x/pdb |
Descriptor | Gasdermin-D, VHH-2, VHH-6, ... (4 entities in total) |
Functional Keywords | gasdermin d, gsdmd, nanobody, vhh, inflammation, pyroptosis, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 157390.29 |
Authors | Kopp, A.,Hagelueken, G.,Geyer, M. (deposition date: 2022-02-25, release date: 2023-09-06, Last modification date: 2023-12-13) |
Primary citation | Kopp, A.,Hagelueken, G.,Jamitzky, I.,Moecking, J.,Schiffelers, L.D.J.,Schmidt, F.I.,Geyer, M. Pyroptosis inhibiting nanobodies block Gasdermin D pore formation. Nat Commun, 14:7923-7923, 2023 Cited by PubMed: 38040708DOI: 10.1038/s41467-023-43707-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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