7YTX

Crystal structure of TLR8 in complex with its antagonist

Summary for 7YTX

• Entry DOI: 10.2210/pdb7ytx/pdb
• Related: 3W3G 5WYX
• Descriptor: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: toll-like receptor 8, inhibitor, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 195397.83

Authors

Shimizu, T.,Sakaniwa, K. (deposition date: 2022-08-16, release date: 2023-09-27)

• Primary citation: Ishizaka, S.T.,Hawkins, L.,Chen, Q.,Tago, F.,Yagi, T.,Sakaniwa, K.,Zhang, Z.,Shimizu, T.,Shirato, M.; A novel Toll-like receptor 7/8-specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus.; Eur.J.Pharmacol., 957:175962-175962, 2023; PubMed: 37544422; DOI: 10.1016/j.ejphar.2023.175962

Experimental method

X-RAY DIFFRACTION (2.9 Å)