7YQF

Crystal structure of PDE4D complexed with glycyrrhisoflavone

Summary for 7YQF

• Entry DOI: 10.2210/pdb7yqf/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: pde4d, complex, glycyrrhisoflavone, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 81391.18

Authors

Liu, J.Y.,Li, M.J.,Xu, Y.C. (deposition date: 2022-08-06, release date: 2023-07-12, Last modification date: 2023-11-29)

• Primary citation: Xu, H.,Li, S.,Liu, J.,Cheng, J.,Kang, L.,Li, W.,Zhong, Y.,Wei, C.,Fu, L.,Qi, J.,Zhang, Y.,You, M.,Zhou, Z.,Zhang, C.,Su, H.,Yao, S.,Zhou, Z.,Shi, Y.,Deng, R.,Lv, Q.,Li, F.,Qi, F.,Chen, J.,Zhang, S.,Ma, X.,Xu, Z.,Li, S.,Xu, Y.,Peng, K.,Shi, Y.,Jiang, H.,Gao, G.F.,Huang, L.; Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19.; Proc.Natl.Acad.Sci.USA, 120:e2301775120-e2301775120, 2023; PubMed: 37094153; DOI: 10.1073/pnas.2301775120

Experimental method

X-RAY DIFFRACTION (1.54 Å)