7YJ2

Cryo-EM structure of SPT-ORMDL3 (ORMDL3-N13A) complex

Summary for 7YJ2

• Entry DOI: 10.2210/pdb7yj2/pdb
• EMDB information: 33869
• Descriptor: Serine palmitoyltransferase 2, Serine palmitoyltransferase 1, ORM1-like protein 3, ... (6 entities in total)
• Functional Keywords: ceramide, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 144288.10

Authors

Xie, T.,Liu, P.,Gong, X. (deposition date: 2022-07-19, release date: 2023-07-05, Last modification date: 2024-03-20)

• Primary citation: Xie, T.,Liu, P.,Wu, X.,Dong, F.,Zhang, Z.,Yue, J.,Mahawar, U.,Farooq, F.,Vohra, H.,Fang, Q.,Liu, W.,Wattenberg, B.W.,Gong, X.; Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis.; Nat Commun, 14:3475-3475, 2023; PubMed: 37308477; DOI: 10.1038/s41467-023-39274-y

Experimental method

ELECTRON MICROSCOPY (2.9 Å)