7YFK

The structure of human pregnane X receptor in complex with an SRC-1 coactivator peptide and a limonoid compound, nomilin

Replaces:  7CHG

Summary for 7YFK

• Entry DOI: 10.2210/pdb7yfk/pdb
• Descriptor: Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1, Nomilin (3 entities in total)
• Functional Keywords: complex, activator, transcription, drug binding, nuclear receptor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 78143.82

Authors

Xia, Y.,Yao, D.,Huang, C.,Cao, Y. (deposition date: 2022-07-08, release date: 2023-06-14, Last modification date: 2023-11-29)

• Primary citation: Fan, S.,Yan, Y.,Xia, Y.,Zhou, Z.,Luo, L.,Zhu, M.,Han, Y.,Yao, D.,Zhang, L.,Fang, M.,Peng, L.,Yu, J.,Liu, Y.,Gao, X.,Guan, H.,Li, H.,Wang, C.,Wu, X.,Zhu, H.,Cao, Y.,Huang, C.; Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.; Nat Commun, 14:3368-3368, 2023; PubMed: 37291126; DOI: 10.1038/s41467-023-39118-9

Experimental method

X-RAY DIFFRACTION (2.1 Å)