7XV8

Crystal structure of the Human TR4 DNA-Binding Domain Homodimer Bound to DR1 Response Element

Summary for 7XV8

• Entry DOI: 10.2210/pdb7xv8/pdb
• Descriptor: Nuclear receptor subfamily 2 group C member 2, DNA (5'-D(*GP*GP*CP*AP*GP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*A)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*CP*TP*GP*C)-3'), ... (5 entities in total)
• Functional Keywords: transcriptional regulation, dna binding, protein-dna complex, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 29017.62

Authors

Liu, Y.,Chen, Z. (deposition date: 2022-05-21, release date: 2022-12-28, Last modification date: 2023-11-29)

• Primary citation: Liu, Y.,Ma, L.,Li, M.,Tian, Z.,Yang, M.,Wu, X.,Wang, X.,Shang, G.,Xie, M.,Chen, Y.,Liu, X.,Jiang, L.,Wu, W.,Xu, C.,Xia, L.,Li, G.,Dai, S.,Chen, Z.; Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation.; Nucleic Acids Res., 51:1443-1457, 2023; PubMed: 36651297; DOI: 10.1093/nar/gkac1259

Experimental method

X-RAY DIFFRACTION (3.199 Å)