7XN9

Crystal structure of SSTR2 and L-054,522 complex

Summary for 7XN9

• Entry DOI: 10.2210/pdb7xn9/pdb
• Descriptor: Somatostatin receptor type 2,Endo-1,4-beta-xylanase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, tert-butyl (2S)-6-azanyl-2-[[(2R,3S)-3-(1H-indol-3-yl)-2-[[4-(2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]carbonylamino]butanoyl]amino]hexanoate (3 entities in total)
• Functional Keywords: g protein-coupled receptor, somatostatin receptor 2, structural protein, signaling protein, signaring protein-inhibitor complex, signaring protein/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 66942.22

Authors

Zhao, W.,Han, S.,Qiu, N.,Feng, W.,Lu, M.,Yang, D.,Wang, M.-W.,Wu, B.,Zhao, Q. (deposition date: 2022-04-28, release date: 2022-08-03, Last modification date: 2023-11-29)

• Primary citation: Zhao, W.,Han, S.,Qiu, N.,Feng, W.,Lu, M.,Zhang, W.,Wang, M.,Zhou, Q.,Chen, S.,Xu, W.,Du, J.,Chu, X.,Yi, C.,Dai, A.,Hu, L.,Shen, M.Y.,Sun, Y.,Zhang, Q.,Ma, Y.,Zhong, W.,Yang, D.,Wang, M.W.,Wu, B.,Zhao, Q.; Structural insights into ligand recognition and selectivity of somatostatin receptors.; Cell Res., 32:761-772, 2022; PubMed: 35739238; DOI: 10.1038/s41422-022-00679-x

Experimental method

X-RAY DIFFRACTION (2.6 Å)