7XIU

Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with nitrofuran methoxy(methoxycarbonyl)phenyl ester

Summary for 7XIU

Entry DOI	10.2210/pdb7xiu/pdb
Descriptor	Reverse Transcriptase RNase H domain, MANGANESE (II) ION, [4-(hydroxymethyl)phenyl] 5-nitrothiophene-2-carboxylate, ... (5 entities in total)
Functional Keywords	ribonuclease, viral protein
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	1
Total formula weight	17352.25
Authors	Lu, H.,Komukai, Y.,Usami, K.,Guo, Y.,Qiao, X.,Nukaga, M.,Hoshino, T. (deposition date: 2022-04-14, release date: 2022-04-27, Last modification date: 2023-11-29)
Primary citation	Lu, H.,Komukai, Y.,Usami, K.,Guo, Y.,Qiao, X.,Nukaga, M.,Hoshino, T. Computational and Crystallographic Analysis of Binding Structures of Inhibitory Compounds for HIV-1 RNase H Activity. J.Chem.Inf.Model., 62:6762-6774, 2022 Cited by PubMed: 36184946 DOI: 10.1021/acs.jcim.2c00537 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation