7XGE

Crystal structure of MCL-1 in complex with computationally designed inhibitor protein

Summary for 7XGE

• Entry DOI: 10.2210/pdb7xge/pdb
• Descriptor: BCL-xL and MCL-1 dual binder 2, Induced myeloid leukemia cell differentiation protein Mcl-1 (3 entities in total)
• Functional Keywords: computational design, apotosis, de novo protein
• Biological source: synthetic construct; More
• Total number of polymer chains: 8
• Total formula weight: 148067.21

Authors

Oh, B.-H.,Kim, S. (deposition date: 2022-04-04, release date: 2022-07-20, Last modification date: 2024-04-03)

• Primary citation: Kim, S.,Park, H.S.,Oh, B.H.; Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently.; Comput Struct Biotechnol J, 20:3019-3029, 2022; PubMed: 35782728; DOI: 10.1016/j.csbj.2022.06.021

Experimental method

X-RAY DIFFRACTION (2.38 Å)