7XDJ

Crystal structure of actinomycin D-echinomycin-d(AGCGCGT/ACGAGCT) complex

Summary for 7XDJ

• Entry DOI: 10.2210/pdb7xdj/pdb
• Related PRD ID: PRD_000001 PRD_000491
• Descriptor: DNA (5'-D(P*AP*GP*CP*GP*CP*GP*T)-3'), DNA (5'-D(P*AP*CP*GP*AP*GP*CP*(BRU))-3'), DSN-ALA-N2C-MVA-DSN-ALA-NCY-MVA, ... (8 entities in total)
• Functional Keywords: g:a mismatch, single-strand dna twist, mismatch binding antibiotic, dna, dna-antibiotic complex, dna/antibiotic
• Biological source: Streptomyces; More
• Total number of polymer chains: 16
• Total formula weight: 27149.21

Authors

Chien, C.M.,Satange, R.B.,Hou, M.H. (deposition date: 2022-03-27, release date: 2022-12-14, Last modification date: 2023-11-29)

• Primary citation: Satange, R.,Kao, S.H.,Chien, C.M.,Chou, S.H.,Lin, C.C.,Neidle, S.,Hou, M.H.; Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism.; Nucleic Acids Res., 50:8867-8881, 2022; PubMed: 35871296; DOI: 10.1093/nar/gkac629

Experimental method

X-RAY DIFFRACTION (2.435 Å)