7X81

The crystal structure of PloI4-C16M/D46A/I137V in complex with exo-2+2 adduct

Summary for 7X81

• Entry DOI: 10.2210/pdb7x81/pdb
• Descriptor: PloI4, (4S,4aS,6aR,8R,9R,11E,12aR,14aS,17E,18aR,18bR)-9-ethyl-4,8,19-trihydroxy-11,12a,13,18a-tetramethyl-2,3,4,4a,6a,7,8,9,10,12a,13,14,18a,18b-tetradecahydro-14a,17-(metheno)cyclobuta[b]naphtho[2,1-j][1]azacyclotetradecine-16,18(1H,15H)-dione (3 entities in total)
• Functional Keywords: ploi4, mutant, 2+2 cyclase, exo-2+2 adduct, lyase
• Biological source: Micromonospora sp.
• Total number of polymer chains: 2
• Total formula weight: 31931.69

Authors

Li, M.,Pan, L.F. (deposition date: 2022-03-10, release date: 2023-02-08, Last modification date: 2023-11-29)

• Primary citation: Wang, H.,Zou, Y.,Li, M.,Tang, Z.,Wang, J.,Tian, Z.,Strassner, N.,Yang, Q.,Zheng, Q.,Guo, Y.,Liu, W.,Pan, L.,Houk, K.N.; A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions.; Nat.Chem., 15:177-184, 2023; PubMed: 36690833; DOI: 10.1038/s41557-022-01104-x

Experimental method

X-RAY DIFFRACTION (2.104 Å)