7X2K

Crystal structure of nanobody Nb70 with antibody 1F11 fab and SARS-CoV-2 RBD

Summary for 7X2K

• Entry DOI: 10.2210/pdb7x2k/pdb
• Descriptor: Spike protein S1, 1F11-H, 1F11-L, ... (6 entities in total)
• Functional Keywords: sars-cov-2, nanobody, spike, receptor binding domain, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV,SARS-CoV-2); More
• Total number of polymer chains: 4
• Total formula weight: 82195.44

Authors

Wang, X.Q.,Zhang, L.Q.,Ren, Y.F.,Li, M.X. (deposition date: 2022-02-25, release date: 2022-12-21, Last modification date: 2023-06-28)

• Primary citation: Li, M.,Ren, Y.,Aw, Z.Q.,Chen, B.,Yang, Z.,Lei, Y.,Cheng, L.,Liang, Q.,Hong, J.,Yang, Y.,Chen, J.,Wong, Y.H.,Wei, J.,Shan, S.,Zhang, S.,Ge, J.,Wang, R.,Dong, J.Z.,Chen, Y.,Shi, X.,Zhang, Q.,Zhang, Z.,Chu, J.J.H.,Wang, X.,Zhang, L.; Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.; Nat Commun, 13:7957-7957, 2022; PubMed: 36575191; DOI: 10.1038/s41467-022-35642-2

Experimental method

X-RAY DIFFRACTION (2.4 Å)